DIC type simulator

Hypercoagulation intensity

Thrombin generation → fibrinogen cleaved to fibrin → microvascular thrombi. Driven by tissue factor, cytokines, NETs.

Hyperfibrinolysis intensity

tPA converts plasminogen → plasmin → degrades fibrin and fibrinogen. Suppressed when PAI-1 is elevated.

Underlying leukemia (bone marrow suppression) Impairs platelet production independently of DIC

Normal hemostasis

Platelet count

250,000

/µL

Consumed primarily by thrombin activation and clot formation

Fibrinogen

350

mg/dL

PT (INR)

1.0

ratio

Prolongs as clotting factors are consumed

D-dimer

200

ng/mL FEU

Rises with both fibrin formation and breakdown

Antithrombin

100

% activity

Consumed inhibiting thrombin and factor Xa

PAI-1

ng/mL

Blocks tPA; elevated by cytokines and LPS in sepsis

Clinical picture

Normal coagulation and fibrinolysis. No pathological activation.